美国博士后招聘-纪念斯隆-凯特琳癌症中心-BRCA1/ 2

发布时间：2020-11-06

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单位：纪念斯隆-凯特琳癌症中心Memorial Sloan Kettering Cancer Center （MSK）

院系：Powell lab

教授：Simon Powell

申请邮箱： powells@mskcc.org

截止日期：November 16, 2020

介绍

纪念斯隆-凯特琳癌症中心（MSK）是世界一流的综合癌症中心，致力于前沿研究，精湛的教育计划和出色的患者护理。将研究与癌症治疗相结合是我们所做工作的核心。我们的任务是治疗和控制癌症，通过实验室研究以及对科学家，医生和其他医护人员的培训来提高生物医学知识。我们位于曼哈顿上东区，在一个充满活力的社区中，包括洛克菲勒大学和康奈尔医学院。这个由三机构组成的区域提供了丰富的协作，学习和社交机会，是数百个美国和国际博士后及其家人的家。

Simon Powell实验室目前提供两个博士后研究员职位。实验室正在寻找对以下感兴趣的候选人：在BRCA1 / 2与复制叉动力学，病变旁路和复制后修复相交方面获取重大发现，以及这些相互关联的过程的研究如何解答基础问题并阐明癌症治疗中的漏洞方面。

鲍威尔实验室有几个方向，重点是同源重组以及BRCA1和BRCA2在细胞对DNA双链断裂和复制压力的反应中的作用。除了保护停滞的复制叉免于降解的机制外，癌细胞还可以绕过许多形式的模板链损坏，其代价是留下了ssDNA缺口（所谓的子链缺口）。缺乏同源重组（HR）的BRCA缺陷细胞依赖于通常容易出错的替代机制来维持复制并防止DNA的形成需要人力资源的中间体。鉴于对允许HR缺陷型癌细胞维持复制的补偿机制的不完全了解，我们最近在不受干扰的BRCA2-/-与BRCA2 + / +细胞中进行了全基因组CRISPR失活筛选，以鉴定合成上具有BRCA2丧失致命性的基因功能。除了已知具有BRCA2功能丧失的合成致死基因（例如POLQ和RAD52），该筛选还揭示了一些新颖的线索，这些线索为实验室打开了重要的新研究领域。

要求

候选人应持有（或即将完成）分子或癌症生物学，生物化学或类似专业的博士学位。

强烈鼓励应聘者熟悉常见分子生物学技术，包括哺乳动物细胞系的组织培养，蛋白质印迹，免疫荧光显微镜检查，流式细胞术和DNA操作。

具有基因组维护（包括DNA纤维分析）的先验经验是优选的，但不是必需的。

申请

有兴趣的申请人应通过电子邮件powells@mskcc.org发送：

简历的副本（PDF格式）

一封求职信：说明其当前和未来的研究兴趣，对先前研究经验和成就的描述以及预计入学日期

三封推荐信的联系方式

Job description

Memorial Sloan Kettering Cancer Center (MSK) is a world premier comprehensive cancer center committed to leading-edge research, superb educational programs, and exceptional patient care. The blending of research with cancer care is at the heart of everything we do. Our missions are to treat and control cancer, advance biomedical knowledge through laboratory research and training of scientists, physicians and other health care workers. We are located in the upper east side of Manhattan, within a vibrant community also comprising the Rockefeller University and Cornell Medical School. This tri-institutional area provides abundant collaborative, learning, and social opportunities and is the home to hundreds of US and international postdocs and their families.

There are currently two postdoctoral research fellow positions available within the laboratory of Simon Powell. The lab is seeking candidates passionate about making impactful discoveries at the intersection of BRCA1/2 and replication fork dynamics, lesion bypass, and post-replicative repair, and how studies of these inter-connected processes answer fundamental questions and shed light on therapeutic vulnerabilities in cancer.

The Powell lab has several interests, with focus on homologous recombination and the role of BRCA1 and BRCA2 in the cellular response to DNA double-strand breaks and replication stress. In addition to the mechanisms that protect stalled replication forks from degradation, cancer cells can bypass many forms of template strand damage, at the cost of leaving behind ssDNA gaps (so-called daughter strand gaps). BRCA-deficient cells lacking homologous recombination (HR) are dependent on alternative, often error prone mechanisms, to sustain replication and prevent the formation of DNA intermediates that require HR. Given the incomplete understanding of compensatory mechanisms that allow for HR-deficient cancer cells to sustain replication, we recently conducted a genome-wide CRISPR inactivation screen in unperturbed BRCA2-/- vs BRCA2+/+ cells to identify genes that are synthetically lethal with BRCA2 loss of function. In addition to genes known to be synthetically lethal with BRCA2 loss of function (e.g. POLQ and RAD52), this screen revealed several novel leads that have opened significant new areas of research for the laboratory.

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