英国博士招聘-伦敦帝国理工学院-人工细胞工程

发布时间：2020-12-09

浏览次数：774次

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公众号链接： https://mp.weixin.qq.com/s?__biz=MzU5NTk2OTE2Mw==&mid=2247485878&idx=1&sn=24eac0f0bace5c71fc48cc86b90af4b0&chksm=fe689c52c91f1544c7af5973fdd8f2a2a1ea5c8b80c028c735853e1e3662ad0d6c801b6f27df&token=530501858&lang=zh_CN#rd

学校：伦敦帝国理工学院 Imperial College London 

院系：Department of Chemical Engineering

教授：Dr. Elani

申请邮箱： y.elani@imperial.ac.uk

截止日期：满额为止

介绍

博士职位：人工细胞工程

伦敦帝国理工学院化学工程系的Elani团队欢迎大家申请本校博士研究生，参与人造细胞工程领域的工作。

生物细胞的核心仅是相互作用分子的复杂关系网络。鉴于此，我们可以提出以下问题：如果我们可以开始建立人造的细胞，将来会怎样呢？我们可以用无生命的东西创造出生命吗？我们是否可以将人工细胞设计为微型机器，在工业和临床环境中发挥设定的功能？

这些问题的答案将为颠覆性应用创造条件，通过建立新的生物学来改变我们对生物学的理解，同时解答了这样的哲学问题——其对生命个体存在什么意义。

近年来，Elani团队的研究一直处于人工细胞工程新兴研究领域的最前沿。通过重新控制生物和合成构件（脂质，酶，膜通道，DNA，纳米粒子等），我们可以对分子进行生物学改造，而不是重新编程活细胞。我们正在探索将合成细胞用作智能药物递送剂，生物传感器，细胞疗法以及药代动力学筛选工具。将活细胞与合成细胞融合以构建杂交“细胞仿生”系统引起了我们的兴趣。

在该博士课程中，候选人将开发新技术来生成基于囊泡的合成细胞，并对它们进行改造，使其具有生命特征：动力，能量生成，交流，复制，决策和自我修复。这将涉及设计和使用新型生物膜，无细胞蛋白质表达系统，基因电路以及微流体技术。这将是一个多学科项目，具体取决于申请人的背景和研究兴趣，将涉及分子生物工程，化学生物学，合成生物学，软物质，膜生物物理学和微流体学中的一项或多项领域。

我们已经获得了两个全额资助职位，可以开展团队内任何领域的研究。这些奖学金面向国内和国际学生开放，并包括津贴，学费和杂费。

要求

申请人应持有或期望获得相关科学或工程学位的一等荣誉硕士学位或硕士二等学位（2：1）（或同等学历）。

申请

如果您有兴趣申请，请发送简历和动机信给Yuval，邮件地址为 y.elani@imperial.ac.uk。

Job description

PhD Position: Artificial Cell Engineering

The Elani Group in the Department of Chemical Engineering at Imperial College London welcomes applications for PhD studentships to conduct work in the area of Artificial Cell Engineering.

Biological cells, at their core, are simply a complex web of interacting molecules. Given this, we can ask the questions: what if we could create entirely artificial cells from scratch? Can we make life from inanimate matter? And can we engineer artificial cells as micromachines that perform bespoke functions in industrial and clinical settings?

Answering these questions will pave the way for disruptive applications, transform our understanding of biology by building a new biology, and shed light on the philosophical question of what it means for something to be alive.

In recent years, the Elani group have been at the forefront of the emerging research area of artificial cell engineering. Instead of re-programming living cells, we engineer biology from the molecule up by controllably bringing together both biological and synthetic building blocks (lipids, enzymes, membrane channels, DNA, nanoparticles etc.). We are exploring the use of synthetic cells as smart drug delivery agents, biosensors, cell therapies and as tools in pharmacokinetic screens. We are increasingly interested in fusing living cells with synthetic ones, to construct hybrid ’cellular bionic’ systems.

In this PhD, the candidate will develop new technologies to generate vesicle-based synthetic cells, and engineer them to possess the behaviours that are the hallmarks of life: motility, energy generation, communication, replication, decision making, and self-repair. This will involve designing and working with novel bio-membranes, cell-free protein expression systems, gene circuits, as well as microfluidic technologies. This will be a multi-disciplinary project which, depending on the applicant’s background and research interest, will span across one or more of molecular bioengineering, chemical biology, synthetic biology, soft matter, membrane biophysics, and microfluidics.

We have secured two fully-funded positions to conduct research in any of the group’s research areas. These scholarships are open to both home and international students, and cover stipend, tuition fees and incidental costs.

Applicants should hold or expect to obtain a First-Class Honours or a high 2:1 degree at Master’s level (or equivalent) in a relevant Science or Engineering degree.

If you are interested in applying, please send a CV and a motivation letter to Yuval at 

y.elani@imperial.ac.uk.

如需申请博士留学，请联系好予博士留学。

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